Abstract #0037

Simultaneous assessment of cardiac metabolism and perfusion using co-polarized [1-13C]pyruvate and 13C-urea

Angus Zoen Lau^1,2, Jack Miller^2,3, Matthew D Robson¹, and Damian J Tyler^1,2

¹Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom, ³Department of Physics, Clarendon Laboratory, Oxford, United Kingdom

Assessment of cardiac metabolism and perfusion using hyperpolarized ¹³C substrates enables discrimination between viable, hibernating, and non-viable tissue, but current methods require two separate injections of pre-polarized [1-¹³C]pyruvate and ¹³C-urea, respectively. We propose to use an infusion of co-polarized [1-¹³C]pyruvate/¹³C-urea combined with a flow-sensitized pulse sequence to simultaneously assess both of these parameters in a single injection. Perfusion and metabolic state are modulated using specific interventions, and subsequently detected using the new scan. This probe of both myocardial perfusion and metabolism is anticipated to enable metabolic study of the heart in acute scenarios.

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