Simultaneous assessment of cardiac metabolism and perfusion using co-polarized [1-13C]pyruvate and 13C-urea
Angus Zoen Lau1,2, Jack Miller2,3, Matthew D Robson1, and Damian J Tyler1,2
1Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom, 3Department of Physics, Clarendon Laboratory, Oxford, United Kingdom
Assessment of cardiac metabolism and perfusion using
hyperpolarized 13C substrates enables discrimination between viable,
hibernating, and non-viable tissue, but current methods require two separate injections
of pre-polarized [1-13C]pyruvate and 13C-urea,
respectively. We propose to use an infusion of co-polarized [1-13C]pyruvate/13C-urea
combined with a flow-sensitized pulse sequence to simultaneously assess both of
these parameters in a single injection. Perfusion and metabolic state are
modulated using specific interventions, and subsequently detected using the new
scan. This probe of both myocardial perfusion and metabolism is anticipated
to enable metabolic study of the heart in acute scenarios.
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