Single-shot MRI
has been constrained to acquisitions in quality magnets and
homogeneous tissues. The present study introduces a methodology that can
deliver such images with good SNR, under much poorer field and/or
multiple shift conditions. These capabilities are achieved based on new
principles whereby images are read using field gradients that are not applied
along the direction being encoded. This enables one to accommodate shifts/inhomogeneities
into the single-scan image generation protocol, without suffering from
miss-registrations, without requiring a priori information for post-acquisition
corrections, and without demanding specialized instrumentation. This enables new
single-shot investigations that have hitherto escaped from MRI’s scope.
