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Abstract #0052

Reduced functional segregation between the default mode network and the executive control network in healthy older adults: a longitudinal study

Kwun Kei Ng1, June C. Lo1, Michael W.L. Chee1, and Juan Zhou1,2

1Duke-NUS Graduate Medical School, Singapore, Singapore, 2Clinical Imaging Research Centre, the Agency for Science, Technology and Research and National University of Singapore, Singapore, Singapore

The effects of age on functional connectivity (FC) of intrinsic connectivity networks (ICNs) have largely been derived from cross sectional studies. Far less is known about longitudinal changes in FC and how they relate to ageing-related cognitive decline. We found progressive loss of functional specialization with ageing evidenced by a decline in intra-network FC within the executive control (ECN) and default mode networks (DMN). In contrast, longitudinal change in FC between ECN and DMN followed a u-shaped trajectory whereby functional segregation between these two networks initially increased over time and later decreased as participants aged. The rate of loss in ECN-DMN functional segregation was associated with decline in processing speed.

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