Abstract #0053

Aging Effect on Creatine Kinase Enzyme Activity in Resting Human Brain: An In Vivo 31P-MT Study at 7T

Byeong-Yeul Lee¹, Xiao-Hong Zhu¹, and Wei Chen¹

¹Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States

In this work, we investigated the aging effect on the enzyme activity of creatine kinase (CK) in healthy human visual cortex at resting state using a newly developed in vivo³¹P magnetization transfer (³¹P-MT) method at 7T. Our results show that there was a strong aging dependence of the CK enzyme activity in the resting brain, implying a significant decline of brain energy metabolism in elderly people. In vivo ³¹P-MT technique should provide a valuable tool for clinical research aiming to study aging-related neurodegenerative diseases such as Alzheimer’s disease, and potentially for other metabolic disorders/diseases.

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