Abstract #0055

Hippocampal subfield diffusivity changes in healthy ageing

Daniel J Cox^1,2, Hamied A Haroon², Daniela Montaldi¹, and Laura M Parkes²

¹School of Psychological Sciences, University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom

Alterations to hippocampal microstructure may precede gross volumetric changes in ageing, and these changes may occur preferentially in different hippocampal subfields. We investigated both established (FA and mADC) and novel (DOC) measurements of diffusion in these regions, in addition to volume, in order to determine where age-related changes occurred. The results showed changes across the majority of subfields for mADC and FA, but only in left CA 2/3 for DOC measures 1, 3 and >3. We suggest this could be related to differential degradation of particular cellular structures in these regions.

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