Abstract #0056

Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-term Memory in Aging Mice

Janet Guo¹, Ailing Lin^1,2, and Vikas Bakshi¹

¹Department of Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, KY, United States, ²Department of Biomedical Engineering, Lexington, KY, United States

Caloric restriction (CR) has been shown to increase healthspan in various species; however, its effects on preserving brain functions in aging remain largely unexplored. We used multimodal neuroimaging (PET/MRI/MRS) and behavioral testing to determine in vivo brain glucose metabolism, energy metabolites, and white matter structural integrity in young and old mice fed with either control or 40% CR diet. Blood glucose and ketone bodies were measured. Our findings suggest CR could slow brain aging, partly due to early shift of energy metabolism caused by lower caloric intake. These results provide rationale for CR-induced sustenance of brain health with extended longevity.

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