Abstract #0057

Age-dependent changes in the BOLD Cerebrovascular Reactivity Curve in Response to Progressive Hypercapnia

Alex Bhogal¹, Jill B de Vis¹, Jeroen C.W. Siero¹, Esben T Petersen², Peter R. Luijten¹, Jeroen Hendrikse¹, Marielle E.P. Philippens³, and Hans Hoogduin⁴

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ³Radiotherapy, UMC Utrecht, Utrecht, Netherlands, ⁴Utrecht, Netherlands

Characterizing healthy, age-related changes in the BOLD-CVR response can provide a reference point from which to distinguish abnormal CVR from the otherwise normal effects of ageing. In this study, we examine age-dependent differences in grey and white matter BOLD-CVR response to progressive hypercapnia between young and elderly subjects.

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