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Abstract #0057

Age-dependent changes in the BOLD Cerebrovascular Reactivity Curve in Response to Progressive Hypercapnia

Alex Bhogal1, Jill B de Vis1, Jeroen C.W. Siero1, Esben T Petersen2, Peter R. Luijten1, Jeroen Hendrikse1, Marielle E.P. Philippens3, and Hans Hoogduin4

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 3Radiotherapy, UMC Utrecht, Utrecht, Netherlands, 4Utrecht, Netherlands

Characterizing healthy, age-related changes in the BOLD-CVR response can provide a reference point from which to distinguish abnormal CVR from the otherwise normal effects of ageing. In this study, we examine age-dependent differences in grey and white matter BOLD-CVR response to progressive hypercapnia between young and elderly subjects.

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