Meeting Banner
Abstract #0059

Consistent detection of age-dependent variations of the longitudinal relaxation time in cortical brain regions investigated by MP2RAGE at 9.4T: influence of correcting for a non-uniform transmit field

Gisela E Hagberg1,2, Jonas Bause1, Thomas Ethofer2,3, Philipp Ehses1, Thomas Dresler3, G Shajan1, Rolf Pohmann1, Cornelia Herbert3, Andreas Fallgatter3, Christoph Laske3, Marina Pavlova2, and Klaus Scheffler1,2

1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, 3General Psychiatry&Psychotherapy, University Hospital Tübingen, Tübingen, Germany

Accurate and precise determination of T1 values is of central importance in clinical studies and for tissue segmentation based on the myeloarchitecture that transcends T1. Here we investigate whether well-described age-dependent changes can be detected by high field T1 relaxometry, and how different transmit field correction methods influence the results. We found that the intrinsic bias correction of the MP2RAGE technique is not sufficient to achieve reliable quantification of T1 at ultra high magnetic fields. But, provided that a correction for transmit field inhomogeneity is performed, T1 maps that consistently reveal age-related changes can be generated. The technique holds promise for investigation of local myeloarchitectonics for neuroscientific and clinical studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here