Abstract #0059

Consistent detection of age-dependent variations of the longitudinal relaxation time in cortical brain regions investigated by MP2RAGE at 9.4T: influence of correcting for a non-uniform transmit field

Gisela E Hagberg^1,2, Jonas Bause¹, Thomas Ethofer^2,3, Philipp Ehses¹, Thomas Dresler³, G Shajan¹, Rolf Pohmann¹, Cornelia Herbert³, Andreas Fallgatter³, Christoph Laske³, Marina Pavlova², and Klaus Scheffler^1,2

¹High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ²Biomedical Magnetic Resonance, University Hospital Tübingen, Tübingen, Germany, ³General Psychiatry&Psychotherapy, University Hospital Tübingen, Tübingen, Germany

Accurate and precise determination of T1 values is of central importance in clinical studies and for tissue segmentation based on the myeloarchitecture that transcends T1. Here we investigate whether well-described age-dependent changes can be detected by high field T1 relaxometry, and how different transmit field correction methods influence the results. We found that the intrinsic bias correction of the MP2RAGE technique is not sufficient to achieve reliable quantification of T1 at ultra high magnetic fields. But, provided that a correction for transmit field inhomogeneity is performed, T1 maps that consistently reveal age-related changes can be generated. The technique holds promise for investigation of local myeloarchitectonics for neuroscientific and clinical studies.

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