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Abstract #0060

Changes in white matter structural connectivity and cortical functional connectivity over the healthy adult lifespan

Adrian Tsang1,2,3, Catherine Lebel1,4, Signe Bray1,4, Brad Goodyear1,2,3, Roberto C. Sotero1, Cheryl McCreary1,3, and Richard Frayne1,2,3

1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, Calgary, AB, Canada, 3Seaman Family MR Research Centre, Calgary, AB, Canada, 4Child and Adolescent Imaging Research Program, Alberta Children's Hospital Research Institute, Calgary, AB, Canada

This study investigates how both structural and functional connectivity (SC and FC) changes in the adult lifespan as well as to explore the relationship between measures that are commonly used for SC and FC in the context of normal aging. A multi-modal analysis using DTI and resting-state fMRI data was performed from 183 healthy participants aged 18 – 87 years. We found that fractional anisotropy (FA) and FC showed similar rate of change and correlation strengths with age in the 7 resting-state networks explored. However none of the SC measures showed significant correlations with FC measure.

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