Abstract #0061

Diagnostic accuracy of MRS for Hereditary Neurodegeneration at 3T and 7T

Uzay E Emir^1,2, Tianmeng Lyu³, Dinesh K Deelchand², James M Joers², Diane Hutter², Christopher M Gomez⁴, Khalaf O Bushara⁵, Lynn E Eberly³, and Gulin Oz²

¹FMRIB Centre, University of Oxford, Oxford, United Kingdom, ²Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ³Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, ⁴Department of Neurology, University of Chicago, Chicago, IL, United States, ⁵Department of Neurology, Medical School, University of Minnesota, Minneapolis, MN, United States

To evaluate diagnostic accuracy of state-of-the-art MRS in early neurodegenerative disease, we measured neurochemical profiles in the vermis, cerebellar hemisphere and brainstem of genetically confirmed subjects with spinocerebellar ataxia type 1 and controls by 3T and 7T 1H MRS. Concentrations of major metabolites obtained at 3T and 7T were strongly correlated. While 3T showed great potential by enabling detection of abnormal metabolite levels even in the presymptomatic stage, the increased sensitivity at 7T enabled group separation with higher significance and identification of subtle neurochemical alterations in early symptomatic disease stage more robustly than at 3T.

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