Abstract #0070

High-resolution T1-mapping using inversion-recovery EPI and application to cortical depth-dependent fMRI at 7 Tesla

Sriranga Kashyap¹, Dimo Ivanov¹, Martin Havlíček¹, Benedikt A Poser¹, and Kâmil Uludağ¹

¹Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

Cortical-depth dependent fMRI usually relies on the definition of depths on an anatomical image (eg. MPRAGE). The geometric dissimilarities of the functional compared to the anatomical data require further spatial processing of the functional data to ensure good co-registration. We propose an alternative approach that uses an optimised inversion-recovery EPI derived T₁ image, whose resolution and readout, hence distortions, are identical to that of the functional data, in order to delineate cortical depths. As a result, the cortical-depth specific fMRI data can be analysed in the native space without any spatial confounds stemming from distortion correction and inaccurate registration.

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