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Abstract #0078

In Vivo Evaluation of Low-grade Cartilage Defects in the Knee using Sodium MRI at 7T

Stefan Zbyn1,2, Vladimir Mlynarik1, Vladimir Juras1, Markus Schreiner1,3, Didier Laurent4, Joerg Goldhahn4, Nicole Getzmann4, Stefan Marlovits5, and Siegfried Trattnig1

1Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria, 2CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, 3Department of Orthopaedics, Medical University Vienna, Vienna, Austria, 4Novartis Institutes for Biomedical Research, Basel, Switzerland, 5Department of Trauma Surgery, Medical University Vienna, Vienna, Austria

To our best knowledge, this is the first report on employing sodium (23Na) MRI for the in vivo evaluation of low-grade cartilage defects in the knee joint. In this 7T study, regions with chondral defect, weight-bearing, and non-weight-bearing femoral cartilage were evaluated in 23Na-images of patients after knee injury. Test-retest comparison showed high robustness and repeatability of sodium data. 23Na-MRI allowed differentiation between normal-appearing cartilage and low-grade chondral defects. 23Na-MRI can be used for noninvasive follow-up of changes in GAG content associated with cartilage degeneration. This method might be particularly useful for the evaluation of cartilage regenerating therapies.

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