Abstract #0082

Radiation-induced inflammatory response in tumor-bearing immune-compromised mice by SPIO-enhanced T2-MRI

Natalie Julie Serkova¹, Kendra M Huber¹, Barbara Frederick², Elizabeth R Kessler³, Thomas W Flaig³, and Brian D Kabanagh²

¹Anesthesiology, University of Colorado Denver, Aurora, CO, United States, ²Radiation Oncology, University of Colorado Denver, Aurora, CO, United States, ³Medical Oncology, University of Colorado Denver, Aurora, CO, United States

Clinically, the radiation treatment (RT) is know to trigger an inflammatory response which can be beneficial for overall anti-cancer treatment efficacy. However, in pre-clinical mouse models, the tumor response to the RT is rather heterogenous. Our hypothesis is that tumor-associated macrophages which drive the pro-inflammatory response to the RT, are expressed differently in various mouse strains based on their genetic make-up. The goal of this study was to non-invasively assess the tumor inflammatory response to the RT based on iron oxide-induced changes in T2-MRI after injection of SPIO nanoparticles in two different mouse models with severely (NOD SCID) and moderately (nu/nu athymic) compromised immune system.

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