Abstract #0083

Neuroimaging of Nipah Virus in a Syrian Hamster Model of Infection

Margaret R. Lentz¹, Dima A. Hammoud², Yu Cong¹, Oscar Rojas¹, David Thomasson¹, Peter B. Jahrling^1,3, and Michael R. Holbrook¹

¹Integrated Research Facility, NIAID, National Institutes of Health, Frederick, MD, United States, ²Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States, ³Emerging Viral Pathogens Section, NIAID, National Insitutes of Health, Frederick, MD, United States

The purpose of this study was to utilize MRI to assess alterations in the brain that occur in a Golden Syrian hamster infected with Nipah virus (NiV) via intranasal inoculation. Within 9 days of exposure to NiV, signal alterations were observed in the olfactory bulb in T₂-weighted and FLAIR images, suggestive of inflammation and edema induced by NiV crossing the olfactory epithelium. The identification of non-invasive imaging biomarkers of acute NiV neurologic disease progression in this animal model could aid in the examination of potential vaccines and therapeutics.

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