Abstract #0109

Brain Glycogen Supercompensation: A Role in the Development of Hypoglycemia Unawareness?

Gulin Oz¹, Mauro DiNuzzo², Anjali Kumar³, Amir Moheet³, Kristine Kubisiak⁴, Lynn E. Eberly⁴, and Elizabeth R. Seaquist³

¹Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, Rome, Italy, ³Medicine, University of Minnesota, Minneapolis, MN, United States, ⁴Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. To assess the role of glycogen supercompensation in the generation of HAAF, we estimated the level of brain glycogen supercompensation following RH using ¹³C MRS and compared it to that following acute hypoglycemia (AH). Glycogen levels were found to increase after both AH and RH, but to a lesser extent after RH. These data suggest that glycogen supercompensation may be an epiphenomenon of HAAF.

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