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Abstract #0109

Brain Glycogen Supercompensation: A Role in the Development of Hypoglycemia Unawareness?

Gulin Oz1, Mauro DiNuzzo2, Anjali Kumar3, Amir Moheet3, Kristine Kubisiak4, Lynn E. Eberly4, and Elizabeth R. Seaquist3

1Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Museo storico della fisica e Centro di studi e ricerche Enrico Fermi, Rome, Italy, 3Medicine, University of Minnesota, Minneapolis, MN, United States, 4Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. To assess the role of glycogen supercompensation in the generation of HAAF, we estimated the level of brain glycogen supercompensation following RH using 13C MRS and compared it to that following acute hypoglycemia (AH). Glycogen levels were found to increase after both AH and RH, but to a lesser extent after RH. These data suggest that glycogen supercompensation may be an epiphenomenon of HAAF.

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