Abstract #0108

A 1H-[13C]-NMR Study for Understanding Antidepressant Action of Lanicemine in Chronic Unpredictable Mild Stress Model of Depression

Pravin K Mishra¹ and Anant Bahadur Patel¹

¹NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Though, ketamine possess rapid antidepressant properties, its use is limited due to addictive and psychotomimetic properties. In the current study, we have evaluated the antidepressant activity of lanicemine in CUMS model of depression by ¹H-[¹³C]-NMR spectroscopy together with infusion of [1,6-¹³C₂]glucose. Exposure of lanicemine restored behavioral phenotype and activity of excitatory and inhibitory neurons in depression.

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