Abstract #0107

Dietary Restriction Improved Memory and Neuronal Metabolism in AβPP-PS1 Mouse Model of Alzheimer’s Disease: A 1H-[13C]-NMR Study

Anant Bahadur Patel¹ and Kamal Saba¹

¹NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Alzheimer's disease (AD) is the most common neurodegenerative disorders. Currently no effective treatment available for AD. Dietary restriction (DR) has been shown to improve longevity in rodents. In the present study, we evaluated the effects of DR on memory and brain energy metabolism in AβPP-PS1 mouse model of AD using ¹H-[¹³C]-NMR spectroscopy in conjunction with infusion of [1,6-¹³C₂]glucose. Our findings suggest that DR intervention had improved the memory and the neuro-metabolic activity in the AD mice.

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