Alzheimer's disease (AD) is the most common neurodegenerative disorders.
Currently no effective treatment available for AD. Dietary restriction (DR) has
been shown to improve longevity in rodents. In the present study, we evaluated
the effects of DR on memory and brain energy metabolism in AβPP-PS1 mouse model of
AD using 1H-[13C]-NMR spectroscopy in conjunction with
infusion of [1,6-13C2]glucose. Our findings suggest that
DR intervention had improved the memory and the neuro-metabolic activity in the
AD mice.
