Abstract #0114

Modulations of cerebral TCA cycle activity studied by hyperpolarized Acetate 13C MRS

Elise Vinckenbosch¹, Mor Mishkovsky¹, Arnaud Comment², and Rolf Gruetter^1,3

¹Laboratory of functional and metabolic imaging, EPFL, Lausanne, Switzerland, ²Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland, ³Department of Radiology, University of Lausanne and Geneva, Lausanne, Switzerland

Hyperpolarized [1-¹³C] acetate enables for in vivo detection of 2-oxoglutarate, a tricarboxylic acid (TCA) cycle intermediate, in intact brain at high field. The aim of this study is to examine saturation substrate dose conditions and to compare it with a partially inhibited TCA cycle model. We conclude that 2-oxoglutarate production rate can be calculated as a function of varying substrate concentrations and is affected as well as the cerebral acetate kinetics by TCA cycle activity modulations.

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