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Abstract #0113

Brain Sodium MRI depicts upper motor neuron involvement in Amyotrophic Lateral Sclerosis patients

Aude-Marie Grapperon1, Adil Maarouf2,3, Annie Verschueren1, Amandine Sevy1, Elisabeth Soulier2, Sylviane Confort-Gouny2, Patrick Viout2, Jean-Philippe Ranjeva2, Maxime Guye2,3, Sharham Attarian1, and Wafaa Zaaraoui2

1APHM, Hôpital Timone, Pôle Neurosciences, Marseille, France, 2CRMBM - CNRS - Aix-Marseille Université, Marseille, France, 3APHM, Hôpital Timone, CEMEREM, Marseille, France

Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that involves the death of upper (in brain) and lower (in spine) motor neurons. As conventional MRI failed to show brain motor neurons impairment in ALS, advanced techniques are needed to improve the diagnosis of the disease and monitor its progression. 23Na brain MRI was performed to 4 ALS patients and showed accumulation of sodium in the primary motor areas in the 3 patients presenting with clinical brain motor neuron signs. Besides, more patients were clinically affected, more the sodium accumulation was extended. In conclusion, sodium accumulation, which is an indicator of neuronal injury, could be a marker of ALS diagnosis and disease progression.

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