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Abstract #0112

Assessing metabolic and structural alterations of brain cells in the APP/PS1/tauP301L mouse model of Alzheimer’s disease using MRS and diffusion-weighted MRS in vivo

Clemence Ligneul1,2, Marco Palombo1,2, Juliette Le Douce1,2, Pierrick Jego1,2, Martine Guillermier1,2, Gilles Bonvento1,2, and Julien Valette1,2

1CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

In this work we use in vivo MRS and diffusion-weighted MRS to detect alterations in cellular metabolism and structure in a triple transgenic APP/PS1/tauP301L mouse model of Alzheimer’s disease. We are able to detect massive remodeling of metabolic content in the hippocampus, as well as subtle but significant variations in diffusion properties of astrocytic metabolites. These results are essentially consistent with the metabolic and structural signature of activated astrocyte, a cell status represented around amyloid plaques.

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