Abstract #0118

The influence of node assignment strategies and track termination criteria on diffusion MRI-based structural connectomics

Chun-Hung Yeh¹, Robert Elton Smith¹, Thijs Dhollander¹, Fernando Calamante¹, and Alan Connelly¹

¹The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

This study highlights the issue of using the common strategy for assigning individual streamlines to an atlas-based brain parcellation. This process is non-trivial and can introduce ambiguity into connectome quantification. In many fibre-tracking algorithms, track termination criteria can cause premature termination of streamlines within WM or CSF, which can result in up to ~50–80% of streamlines failing in identifying pairwise connections between nodes from streamline endpoints. Our results demonstrate that such issue can be largely ameliorated through the combination of biologically meaningful track terminations and an appropriate node assignment mechanism. This could therefore be advantageous to structural connectome construction.

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