Abstract #0123

Fibers crossing the white/gray matter boundary: a semi-global, histology-informed dMRI model

Michiel Cottaar¹, Matteo Bastiani¹, Charles Chen², Krikor Dikranian², David C. Van Essen², Timothy E. Behrens¹, Stamatios N. Sotiropoulos¹, and Saad Jbabdi¹

¹FMRIB, Oxford University, Oxford, United Kingdom, ²Washington University School of Medicine, Saint Louis, MO, United States

Close to the cortical white/gray matter boundary surface fiber orientations sharply transition from being nearly tangential to the surface in the white matter to mostly radial in the gray matter. We propose a geometric model that describes this transition at sub-voxel resolution based on high-resolution histology data and fit this model to lower resolution diffusion MRI data. We assess its performance using qualitative comparisons with histology and test the reproducibility of the estimated parameters across multiple diffusion MRI resolutions. This model allows the in-vivo estimation of fiber orientations across the white/gray matter boundary, which may improve tracking to the cortex.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.