Abstract #0124

Microscopic DTI for quantitative tractography of MAP6-KO mice: validation by fluorescent microscopy on cleared brains

Ulysse Gimenez¹, Franck Mauconduit¹, Benoit Boulan², Eric Denarier², Jacques Brocard², Sylvie Gory-Fauré², Annie Andrieux², Jean Christophe Deloulme², and Hana Lahrech¹

¹Clinatec Lab U1205, INSERM, Grenoble, France, ²Grenoble Institute of Neurosciences, INSERM, La Tronche, France

High spatial resolution 3D DTI was developed and used for white matter tractography to quantify neuronal tract alterations on the MAP6-KO mouse. In this model, the microtubule-associated protein 6 (MAP6) which is involved in the neuromorphogenesis is deleted leading to a model characterized by severe behavior impairments, similar to the clinical features of schizophrenia. As 3D DTI tractography and fluorescent microscopy on cleared brains both show a deficiency of the post-commissural fornix, in accordance with our previous 2D DTI results, the 3D DTI tractography imaging is validated. Using 3D DTI tractography, new major alterations in different neuronal tracts are detected.

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