Ulysse Gimenez1, Franck Mauconduit1, Benoit Boulan2, Eric Denarier2, Jacques Brocard2, Sylvie Gory-Fauré2, Annie Andrieux2, Jean Christophe Deloulme2, and Hana Lahrech1
1Clinatec Lab U1205, INSERM, Grenoble, France, 2Grenoble Institute of Neurosciences, INSERM, La Tronche, France
High spatial resolution
3D DTI was developed and used for white matter tractography to quantify neuronal
tract alterations on the MAP6-KO mouse. In this model, the
microtubule-associated protein 6 (MAP6) which is involved in the
neuromorphogenesis is deleted leading to a model characterized by severe behavior
impairments, similar to the clinical features of schizophrenia. As 3D DTI tractography and
fluorescent microscopy on cleared brains both show a deficiency of the
post-commissural fornix, in accordance with our previous
2D DTI results, the 3D DTI tractography imaging is validated. Using 3D DTI
tractography, new major alterations in different neuronal tracts are detected.
