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Abstract #0124

Microscopic DTI for quantitative tractography of MAP6-KO mice: validation by fluorescent microscopy on cleared brains

Ulysse Gimenez1, Franck Mauconduit1, Benoit Boulan2, Eric Denarier2, Jacques Brocard2, Sylvie Gory-Fauré2, Annie Andrieux2, Jean Christophe Deloulme2, and Hana Lahrech1

1Clinatec Lab U1205, INSERM, Grenoble, France, 2Grenoble Institute of Neurosciences, INSERM, La Tronche, France

High spatial resolution 3D DTI was developed and used for white matter tractography to quantify neuronal tract alterations on the MAP6-KO mouse. In this model, the microtubule-associated protein 6 (MAP6) which is involved in the neuromorphogenesis is deleted leading to a model characterized by severe behavior impairments, similar to the clinical features of schizophrenia. As 3D DTI tractography and fluorescent microscopy on cleared brains both show a deficiency of the post-commissural fornix, in accordance with our previous 2D DTI results, the 3D DTI tractography imaging is validated. Using 3D DTI tractography, new major alterations in different neuronal tracts are detected.

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