Abstract #0125

Network integration and segregation differentiate between Alzheimer Disease and Vascular Dementia

Fulvia Palesi^1,2, Andrea De Rinaldis^2,3, Letizia Casiraghi^2,4, Gloria Castellazzi^2,3, Paolo Vitali⁵, Nicoletta Anzalone⁶, Federica Denaro⁷, Elena Sinforiani⁸, Giuseppe Micieli⁷, Egidio D'Angelo^2,4, and Claudia Angela Michela Gandini Wheeler-Kingshott^2,9

¹Department of Physics, University of Pavia, Pavia, Italy, ²Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, ³Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, ⁴Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ⁵Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Scientific Institute H. S. Raffaele, Milan, Italy, ⁷Department of Emergency Neurology, C. Mondino National Neurological Institute, Pavia, Italy, ⁸Alzheimer's Disease Assessment Unit, Laboratory of Neuropsychology, C. Mondino National Neurological Institute, Pavia, Italy, ⁹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom

Dementia is the most common disorder in elderly people and comprises Alzheimer’s disease (AD) and vascular disease (VaD). In this work graph theoretical approach was applied to a cohort of AD, VaD and healthy controls (HC) aimed at investigating the presence of a disease-specific pattern of alterations. Brain structural networks were built using the Cohen functional atlas (nodes) and advanced probabilistic tractography (edges). Our main finding was that VaD patients showed severe impairment in the large-scale brain networks while AD patients mainly showed inefficiency of short-range connections emphasizing the fact that alterations are restricted to specific brain regions.

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