Abstract #0132

MRI in predicting the response of gastrointestinal stromal tumor to targeted therapy: a patient-based multi-parameter study

Lei Tang¹, Jian Li², Ying-Shi Sun¹, Xiao-Ting Li¹, Zi-Yu Li³, Xiao-Yan Zhang¹, and Lin Shen ²

¹Radiology, Peking University Cancer Hospital & Institute, Beijing, China, People's Republic of, ²GI medicine, Peking University Cancer Hospital & Institute, Beijing, China, People's Republic of, ³GI surgery, Peking University Cancer Hospital & Institute, Beijing, China, People's Republic of

The percentage changes of the ADC in GIST after two weeks of targeted therapy exhibited reliable performance in response prediction, and these variables outperformed T2WI-CNR and the longest diameter. We suggest that patients continue their treatment regimens if the percentage increases in the ADC are no less than 15% after two weeks of therapy. In contrast, if the ADC decreases or exhibits almost no change, then a shortening of the follow-up time intervals is highly recommended to detect possible drug resistance at an early stage.

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