Abstract #0152

In Vivo Visualization of Iron-Rich Amyloid Plaques In Cholesterol-Fed Rabbits using Clinical Field-Strength Magnetic Resonance Imaging

Yuanxin Chen¹, Yong Wang^1,2, Kem A Rogers¹, John A Ronald¹, and Brian K Rutt³

¹Western University, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Stanford University, Stanford, CA, United States

Hypercholesterolemia is a risk factor for AD and promotes increased production of beta-amyloid protein. Our lab has developed a rabbit model of AD by enriching the diets of rabbits with low amounts of cholesterol. In this study, we combined this cholesterol-fed rabbit model of AD with iron-sensitive, high-resolution MRI and demonstrated non-invasive in vivo visualization of AD plaques throughout the brains of these animals. The imaging techniques have been developed and optimized using a clinical field strength scanner (3T), which is an important step towards clinical application in human AD patients.

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