4D Flow MRI for assessing flow pulsatility along the carotid siphon in Alzheimer’s disease
Leonardo A Rivera-Rivera1, Tilman Schubert2, Kevin M Johnson1, Sterling C Johnson3, Oliver Wieben1,2, and Patrick Turski2
1Medical Physics, University of Wisconsin Madison, Madison, WI, United States, 2Radiology, University of Wisconsin Madison, Madison, WI, United States, 3Medicine, University of Wisconsin Madison, Madison, WI, United States
Cerebral arteries are often morphologically altered and
dysfunctional in Alzheimer’s disease (AD). In this study, 4D flow MRI was used
to assess flow pulsatility along the carotid siphon in patients with AD, mild cognitive
impairment (MCI) and in healthy age matched controls. We found the physiologic dampening of pulsatility along
the distal ICA is significantly diminished in patients with AD. With the
large volume coverage and high temporal and spatial resolution, 4D flow MRI can
provide additional biomarkers of vascular health that can contribute to the
identifying patients who could benefit from interventions to improve
circulatory system functions.
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