Abstract #0151

4D Flow MRI for assessing flow pulsatility along the carotid siphon in Alzheimer’s disease

Leonardo A Rivera-Rivera¹, Tilman Schubert², Kevin M Johnson¹, Sterling C Johnson³, Oliver Wieben^1,2, and Patrick Turski²

¹Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ²Radiology, University of Wisconsin Madison, Madison, WI, United States, ³Medicine, University of Wisconsin Madison, Madison, WI, United States

Cerebral arteries are often morphologically altered and dysfunctional in Alzheimer’s disease (AD). In this study, 4D flow MRI was used to assess flow pulsatility along the carotid siphon in patients with AD, mild cognitive impairment (MCI) and in healthy age matched controls. We found the physiologic dampening of pulsatility along the distal ICA is significantly diminished in patients with AD. With the large volume coverage and high temporal and spatial resolution, 4D flow MRI can provide additional biomarkers of vascular health that can contribute to the identifying patients who could benefit from interventions to improve circulatory system functions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.