Abstract #0150

Brain phospholipid and energy metabolism in mild Alzheimer’s disease and healthy aging: a 31P Magnetic Resonance Spectroscopy study

Anne Rijpma^1,2, Marinette van der Graaf^3,4, Olga Meulenbroek^1,2, Marcel Olde Rikkert^1,2, and Arend Heerschap³

¹Geriatric Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Radboud Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, Netherlands, ³Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ⁴Paediatrics, Radboud university medical center, Nijmegen, Netherlands

In this study we assessed phospholipid and energy metabolism in patients with mild Alzheimer’s disease and healthy age-matched control subjects by 3D ³¹P MRS imaging. Four brain regions were investigated: left and right hippocampus, anterior cingulate cortex, and retrosplenial cortex. Disease specific differences as well as differences between brain regions were found.

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