Abstract #0149

1H-[13C]-NMR Investigation of Neuroprotective Action of Ayurvedic Formulation in AβPP-PS1 Mouse Model of Alzheimer’s Disease

Kamal Saba¹, Niharika Rajnala¹, and Anant Bahadur Patel¹

¹NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Currently no definite treatment available for AD. We have examined the efficacy of Rasa Sindoor, an Ayurvedic formulation, for the improvement of memory and neuronal activity in AβPP-PS1 mouse model of AD. Neuronal metabolism was followed by ¹H-[¹³C]-NMR spectroscopy together with an infusion of [1,6-¹³C₂]glucose. Our results indicate that the Rasa-Sindoor improved memory, and excitatory and inhibitory neuronal metabolic activity in AD mice.

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