Abstract #0148

High resolution MR elastography of the hippocampus reveals differential tissue elasticity in Alzheimer's disease – a pilot study

Andreas Fehlner¹, Lea M Gerischer², Agnes Flöel^2,3, Jürgen Braun⁴, and Ingolf Sack¹

¹Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ³NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Multifrequency MR elastography (MMRE) was applied to 14 patients with Alzheimer's disease (AD) and compared to 14 age matched asymptomatic controls. We observed a marked decrease of the white-matter complex shear modulus |G*| in patients with AD. This reduction in |G*| was even more pronounced in the hippocampal region. In this region a diagnostic performance of 78% sensitivity and 92% specificity (AUROC-value 0.918) was obtained based on a viscoelasticity cutoff value of 0.9 kPa. In the future MMRE-measured |G*| could serve as a quantitative imaging marker for early diagnosis and progression monitoring of AD.

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