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Abstract #0147

MR Elastography Demonstrates Unique Regional Brain Stiffness Patterns in Dementias

Mona ElSheikh1, Arvin Arani1, Avital Perry2, Nealey Cray2, Fredric Meyer2, David Lake1, Armando Manduca3, Kevin Glaser1, Richard L Ehman1, and John Huston1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Neurosurgery, Mayo Clinic, Rochester, MN, United States, 3Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

The development of advanced MRI techniques has enabled noninvasive evaluation of subtle changes of brain architecture in dementia. We report a specific pattern of regional brain stiffness changes using Magnetic Resonance Elastography (MRE) in three different dementia groups: Alzheimer’s disease, frontotemporal dementia, and normal pressure hydrocephalus. MRE offers a potential biomarker to characterize the viscoelastic properties of the brain in dementia patients, and may have a role in the diagnosis and differentiation between common subtypes of dementia.

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