To investigate the altered pattern of DMN in amnestic mild cognitive impairment (aMCI)
subjects and the genetic factors that lead to the DMN dysfunctions, 87 individuals with aMCI and 131
matched healthy controls were recruited and an average 3-year follow-up study
was performed. We studied the differences of DMN between aMCI subjects and
healthy controls at baseline and how the DMN changed over time. Regression analyses
were performed to explore whether the GRS influence the DMN dysfunctions. We
observed that DMN disengage in the early stage of AD and the combined effect of AD-related loci
influence the DMN pattern.