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Abstract #0155

The effect of Alzheimer's disease on the viscoelasticity of the mouse brain under the influence of enriched environment.

Jing Guo1, Tonia Munder2, Charlotte Klein2, Anna Pfeffer2, Jürgen Braun3, Barbara Steiner2, and Ingolf Sack1

1Department of Radiology, Charité - University Medicine Berlin, Berlin, Germany, 2Department of Neurology, Charité - University Medicine Berlin, Berlin, Germany, 3Institute of Medical Informatics, Charité - University Medicine Berlin, Berlin, Germany

MRE was used to study environmental influences on viscoelasticity of the murine hippocampus in Alzheimer's disease (AD). In wild type control mice, hippocampal viscosity was significantly increased within 6 months while elasticity remained unchanged. This suggests that environment-stimulated neuronal proliferation adds mobile elements to the mechanical matrix of the brain which increases mechanical attenuation properties. Within 6 months, AD caused a decline of hippocampal viscosity only in the enriched environment while standard mouse remained unaffected suggesting that AD in an early phase primarily affects new neurons in the murine hippocampus.

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