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Abstract #0156

A preliminary study on MR amide proton imaging in patients with Alzheimer’s disease and mild cognitive impairment

Rui Wang1, Chunmei Li1, Yongming Dai2, Dantao Peng3, Xuna Zhao4, and Min Chen1

1Radiology, Beijing Hospital, Beijing, China, People's Republic of, 2Philips Heathcare, Shanghai, China, People's Republic of, 3China-Japan Friendship Hospital, Beijing, China, People's Republic of, 4Philips Heathcare, Beijing, China, People's Republic of

The aim of this study is to evaluate the feasibility of MR amide proton transfer (APT) imaging for the detection of cerebral abnormalities in patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI), and to explore its clinical utility. Twenty-one AD patients, 11 aMCI patients and 19 normal controls (NC) underwent APT MR imaging. The magnetic resonance ratio asymmetry (MTRasym) values at 3.5ppm of bilateral hippocampi, temporal white matter regions, occipital white matter regions and cerebral peduncles were measured on the oblique APT images. We found that MTRasym(3.5ppm)asym in bilateral hippocampi showed a consistently increasing trend from NC to MCI, to AD. MTRasym(3.5ppm) values of bilateral hippocampi were significantly negatively correlated with MMSE. Our results suggested that APT imaging is a useful tool to diagnose early AD and monitor the disease.

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