Abstract #0157

MR elastography and DCE-MRI of the liver and spleen for non-invasive prediction of portal pressure

Stefanie Hectors¹, Mathilde Wagner¹, Octavia Bane¹, Aaron Fischman², Thomas Schiano³, and Bachir Taouli^1,4

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Interventional Radiology, Icahn School of Medicine at Mount SInai, New York, NY, United States, ³Department of Internal Medicine, Icahn School of Medicine at Mount SInai, New York, NY, United States, ⁴Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of this study was to assess whether DCE-MRI parameters and MR elastography-derived stiffness in liver and spleen can predict portal pressure. Liver time-to-peak (TTP), mean transit time (MTT), upslope and stiffness (LS) all significantly correlated with hepatic venous pressure gradient (HVPG) measurement. Sensitivity-specificity of LS for detection of HVPG≥5mmHg and HVPG≥10mmHg were 64%-91% and 71%-89% respectively, while combined LS and spleen TTP yielded the highest sensitivity-specificity (92%-86% for HVPG≥5mmHg, 100%-92% for HVPG≥10mmHg). These results indicate that combination of liver and spleen perfusion and stiffness metrics into a multiparametric analysis maximizes diagnostic performance for the prediction of portal pressure.

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