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Abstract #0157

MR elastography and DCE-MRI of the liver and spleen for non-invasive prediction of portal pressure

Stefanie Hectors1, Mathilde Wagner1, Octavia Bane1, Aaron Fischman2, Thomas Schiano3, and Bachir Taouli1,4

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Interventional Radiology, Icahn School of Medicine at Mount SInai, New York, NY, United States, 3Department of Internal Medicine, Icahn School of Medicine at Mount SInai, New York, NY, United States, 4Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of this study was to assess whether DCE-MRI parameters and MR elastography-derived stiffness in liver and spleen can predict portal pressure. Liver time-to-peak (TTP), mean transit time (MTT), upslope and stiffness (LS) all significantly correlated with hepatic venous pressure gradient (HVPG) measurement. Sensitivity-specificity of LS for detection of HVPG≥5mmHg and HVPG≥10mmHg were 64%-91% and 71%-89% respectively, while combined LS and spleen TTP yielded the highest sensitivity-specificity (92%-86% for HVPG≥5mmHg, 100%-92% for HVPG≥10mmHg). These results indicate that combination of liver and spleen perfusion and stiffness metrics into a multiparametric analysis maximizes diagnostic performance for the prediction of portal pressure.

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