Abstract #0158

Longitudinal assessment of structural and haemodynamic parameters in compensated cirrhosis using Quantitative Magnetic Resonance Imaging

Chris Bradley¹, Eleanor F Cox¹, David Harman², Martin W James², Guru P Aithal², I Neil Guha², and Susan T Francis¹

¹Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases, University of Nottingham, Nottingham, United Kingdom

We perform a longitudinal 3 year study to assess progression of disease in compensated cirrhosis (CC) using annual haemodynamic and structural MR measures, and compare with a healthy volunteer group. Longitudinal relaxation time (T₁) correlates with liver disease severity, and shows a small variance across years in stable, compensated cirrhosis. In contrast a large variance is shown for liver stiffness measures using Fibroscan®. MR measures correlate well with Enhanced Liver Fibrosis (ELF) scores. This study suggests that MR provides a sensitive technique to assess changes in pathophysiology of CC.

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