Abstract #0162

Measurement of bulk liver perfusion: Assessment of agreement between ASL and caval subtraction phase-contrast MRI at 9.4T

Manil Chouhan¹, Rajiv Ramasawmy², Alan Bainbridge³, Adrienne Campbell-Washburn², Jack Wells², Shonit Punwani¹, Rajeshwar Mookerjee⁴, Simon Walker-Samuel², Mark Lythgoe², and Stuart Taylor¹

¹UCL Centre for Medical Imaging, University College London, London, United Kingdom, ²UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ³Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, ⁴UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom

Non-invasive preclinical liver perfusion measurements could be used to develop biomarkers and assess new treatments for liver disease and primary/secondary malignant liver lesions. ASL can provide regional hepatic perfusion maps, and in this study we compare FAIR ASL tissue perfusion measurements with caval subtraction phase-contrast MRI, a validated method for measuring total liver blood flow, to demonstrate ASL overestimation but encouraging agreement between both methods.

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