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Abstract #0162

Measurement of bulk liver perfusion: Assessment of agreement between ASL and caval subtraction phase-contrast MRI at 9.4T

Manil Chouhan1, Rajiv Ramasawmy2, Alan Bainbridge3, Adrienne Campbell-Washburn2, Jack Wells2, Shonit Punwani1, Rajeshwar Mookerjee4, Simon Walker-Samuel2, Mark Lythgoe2, and Stuart Taylor1

1UCL Centre for Medical Imaging, University College London, London, United Kingdom, 2UCL Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 3Department of Medical Physics, University College London Hospitals NHS Trust, London, United Kingdom, 4UCL Institute for Liver and Digestive Health, University College London, London, United Kingdom

Non-invasive preclinical liver perfusion measurements could be used to develop biomarkers and assess new treatments for liver disease and primary/secondary malignant liver lesions. ASL can provide regional hepatic perfusion maps, and in this study we compare FAIR ASL tissue perfusion measurements with caval subtraction phase-contrast MRI, a validated method for measuring total liver blood flow, to demonstrate ASL overestimation but encouraging agreement between both methods.

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