Abstract #0166

The change and interrelation of quantitative hepatic MR imaging biomarkers in the course of chronic hepatitis.

Akira Yamada¹, Yasunari Fujinaga¹, Yoshihiro Kitoh², Takeshi Suzuki¹, Daisuke Komatsu¹, Aya Shiobara², Yasuo Adachi², Atsushi Nozaki³, Yuji Iwadate³, Kazuhiko Ueda¹, and Masumi Kadoya¹

¹Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan, ²Division of Radiology, Shinshu University Hospital, Matsumoto, Japan, ³GE Healthcare Japan, Hino, Japan

Variable quantitative hepatic imaging biomarkers including pharmacokinetic parameters of hemodynamics and hepatocellular uptake function, R2* and fat fraction, apparent diffusion coefficient (ADC), liver stiffness were obtained from the patients with chronic hepatitis using MR imaging. The change and interrelation of these imaging biomarkers in the course of chronic hepatitis were evaluated quantitatively. Portal venous inflow and hepatocellular uptake function correlated well with liver stiffness, meanwhile, ADC showed weak correlation. Arterial compensation, decreased blood flow speed and volume were observed in the patients with decreased portal venous inflow. No significant correlation was observed between liver stiffness and R2* or fat fraction.

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