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Abstract #0166

The change and interrelation of quantitative hepatic MR imaging biomarkers in the course of chronic hepatitis.

Akira Yamada1, Yasunari Fujinaga1, Yoshihiro Kitoh2, Takeshi Suzuki1, Daisuke Komatsu1, Aya Shiobara2, Yasuo Adachi2, Atsushi Nozaki3, Yuji Iwadate3, Kazuhiko Ueda1, and Masumi Kadoya1

1Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan, 2Division of Radiology, Shinshu University Hospital, Matsumoto, Japan, 3GE Healthcare Japan, Hino, Japan

Variable quantitative hepatic imaging biomarkers including pharmacokinetic parameters of hemodynamics and hepatocellular uptake function, R2* and fat fraction, apparent diffusion coefficient (ADC), liver stiffness were obtained from the patients with chronic hepatitis using MR imaging. The change and interrelation of these imaging biomarkers in the course of chronic hepatitis were evaluated quantitatively. Portal venous inflow and hepatocellular uptake function correlated well with liver stiffness, meanwhile, ADC showed weak correlation. Arterial compensation, decreased blood flow speed and volume were observed in the patients with decreased portal venous inflow. No significant correlation was observed between liver stiffness and R2* or fat fraction.

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