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Abstract #0165

Comparison of the Hepatocyte Fraction and Conventional Image Based Methods for the Estimation of Liver Function

Tomoyuki Okuaki1, Kosuke Morita2, Tomohiro Namimoto3, Morikatsu Yoshida3, Shinya Shiraishi3, Masanori Komi2, Yasuyuki Yamashita3, and Marc Van Cauteren1

1Philips Healthcare, Tokyo, Japan, 2Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan, 3Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

The hepatocyte fraction (HeF) is based on simple pharmacokinetics, and can quantitatively estimate the fraction of hepatocytes. In this study, the HeF, liver-spleen contrast ratio and delta T1 value were compared to the results of 99mTc-GSA scintigraphy using the blood clearance index (HH15) and receptor index (LHL15). The correlation coefficients of the HH15 were 0.602, 0.544 and 0.773, respectively, and of the LHL15 were 0.612, 0.670 and 0.762, respectively. The HeF quantification showed the highest correlation with the 99mTc-GSA, proving it to be useful for a robust evaluation of liver function, compared to conventional imaging based quantitative methods.

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