Abstract #0165

Comparison of the Hepatocyte Fraction and Conventional Image Based Methods for the Estimation of Liver Function

Tomoyuki Okuaki¹, Kosuke Morita², Tomohiro Namimoto³, Morikatsu Yoshida³, Shinya Shiraishi³, Masanori Komi², Yasuyuki Yamashita³, and Marc Van Cauteren¹

¹Philips Healthcare, Tokyo, Japan, ²Department of Central Radiology, Kumamoto University Hospital, Kumamoto, Japan, ³Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

The hepatocyte fraction (HeF) is based on simple pharmacokinetics, and can quantitatively estimate the fraction of hepatocytes. In this study, the HeF, liver-spleen contrast ratio and delta T1 value were compared to the results of ^99mTc-GSA scintigraphy using the blood clearance index (HH15) and receptor index (LHL15). The correlation coefficients of the HH15 were 0.602, 0.544 and 0.773, respectively, and of the LHL15 were 0.612, 0.670 and 0.762, respectively. The HeF quantification showed the highest correlation with the ^99mTc-GSA, proving it to be useful for a robust evaluation of liver function, compared to conventional imaging based quantitative methods.

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