Abstract #0177

Bound- and Pore-Water MRI of Cortical Bone in Osteoporotic Patients

Mary Kate Manhard¹, S Bobo Tanner², Daniel F Gochberg³, Jeffry S Nyman⁴, and Mark D Does¹

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Department of Medicine, Vanderbilt University, Nashville, TN, United States, ³Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁴Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States

Osteoporotic fractures are a growing problem, and X-ray based methods do not always identify individuals at risk of a fracture. MRI based methods of bound and pore water in cortical bone have the potential to offer new information about fracture resistance. These methods were implemented on both osteoporotic volunteers and healthy controls in the tibia. Osteoporotic subjects had significant decreases in bound water concentration and slight increases in pore water concentration compared to healthy subjects. These promising results will allow for further investigation of changes of bound and pore water concentrations across diseases and with response to various treatment methods.

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