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Abstract #0178

Magnetic resonance elastography characterization of skeletal muscle stiffness changes resulting from pressure ulcers

Jules Laurent Nelissen1,2, Willeke Traa3, Larry de Graaf1, Kevin Moerman4, Cees Oomens3, Aart Nederveen5, Ralph Sinkus6, Klaas Nicolay1, and Gustav Strijkers2

1Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands, 2Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands, 3Biomechanics of Soft Tissues, Eindhoven University of Technology, Eindhoven, Netherlands, 4MIT media lab, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Radiology, Academic Medical Center, Amsterdam, Netherlands, 6Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom

We have investigated the feasibility of using Magnetic Resonance Elastography (MRE) to quantify muscle-tissue mechanical properties and changes therein related to the development of deep tissue injury type of pressure ulcers. MRE measurements were performed before and after damage-inducing indentation of the tibialis-anterior muscle of Sprague Dawley rats. Current study demonstrates that changes in muscle-tissue mechanical properties associated with deep tissue injury can be quantified by MRE. We expect that better knowledge of changes in soft tissue mechanical properties due to damage, measured with MRE, will provide new insights in the aetiology of deep tissue injury and other muscle pathologies.

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