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Abstract #0179

Selective in Vivo Bone Imaging with Long-T2 suppressed PETRA MRI

Cheng Li1, Jeremy F. Magland1, Xia Zhao1, Alan C. Seifert2, and Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States

An IR-based long-T2 suppressed PETRA sequence was designed and optimized to image sub-millisecond-T2 tissue components, e.g. collagen-bound bone water. To minimize scan time signal was sampled repeatedly after each inversion with individual excitation flip-angle designed to yield constant short-T2 signal amplitude. A fast non-iterative reconstruction algorithm combined with phase-modulated excitation pulse was applied to minimize image artifacts due to non-uniform excitation profile, allowing for increased flip-angle and higher SNR. Optimized long-T2 suppressed PETRA allows imaging of bone matrix water, opening up new possibilities for anatomic bone imaging at isotropic resolution and quantification in clinically practical scan times.

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