Abstract #0192

In vivo measurement of tumor T1 relaxation time using a whole body clinically feasible multiple flip angle method can predict response to chemotherapy

Harbir Singh Sidhu¹, Anna Barnes², Nikolaos Dikaios¹, Scott Rice¹, Alan Bainbridge³, Robert Stein⁴, Sandra Strauss⁵, David Atkinson¹, Stuart Taylor¹, and Shonit Punwani¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Institute of Nuclear Medicine, University College London Hospital, London, United Kingdom, ³Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, ⁴Medical Oncology, University College London Hospital, London, United Kingdom, ⁵Research Department of Oncology, University College London, London, United Kingdom

Tumor response assessment currently relies upon measurement of size change, which may not alter significantly early during treatment or at all with newer therapies. Patients may therefore incur significant side-effects (with associated healthcare cost) without benefit. Assessment of soft tissue tumor T1 relaxation times before and early during treatment can predict lesion response whilst being incorporated within a clinically feasible whole-body MRI scan duration. Tumors undergoing partial response at the end of treatment demonstrated significant reduction in T1 values early during therapy compared to non-responding lesions.

In the future, this could facilitate early response assessment and complement other imaging biomarkers.

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