Eoin Finnerty1, Rajiv Ramasawmy2, James O'Callaghan2, Mark F Lythgoe2, Karin Shmueli1, David L Thomas3, and Simon Walker-Samuel2
1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2University College London, London, United Kingdom, 3Institute of Neurology, University College London, London, United Kingdom
This work examines the application of
Quantitative Susceptibility Mapping (QSM) in a mouse model of colorectal liver
metastases. It was hypothesised that QSM could provide a novel method of
interrogation of liver tumours based on differences in blood oxygenation.
Results under hyperoxic and normoxic conditions were compared to assess the
response of the liver tissue and tumours. A vascular disrupting agent was then
administered to assess its effect on the QSM measurements. A significant
difference was found between liver and tumour tissue, and regional differences
in susceptibility were found within a tumour. These differences were less
apparent after VDA administration.