Abstract #0193

Quantitative Susceptibility Mapping to Interrogate Colorectal Metastases in Mouse Liver during Normoxia and Hyperoxia

Eoin Finnerty¹, Rajiv Ramasawmy², James O'Callaghan², Mark F Lythgoe², Karin Shmueli¹, David L Thomas³, and Simon Walker-Samuel²

¹Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²University College London, London, United Kingdom, ³Institute of Neurology, University College London, London, United Kingdom

This work examines the application of Quantitative Susceptibility Mapping (QSM) in a mouse model of colorectal liver metastases. It was hypothesised that QSM could provide a novel method of interrogation of liver tumours based on differences in blood oxygenation. Results under hyperoxic and normoxic conditions were compared to assess the response of the liver tissue and tumours. A vascular disrupting agent was then administered to assess its effect on the QSM measurements. A significant difference was found between liver and tumour tissue, and regional differences in susceptibility were found within a tumour. These differences were less apparent after VDA administration.

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