Abstract #0206

Preliminary evaluation of R2*-based temperature mapping for predicting the kill zone in MRI-guided renal cryoablation

Junichi Tokuda¹, Kemal Tuncali¹, Lisanne Kok^1,2, Vincent M Levesque ¹, Ravi T Seethamraju ³, Clare M Tempany¹, and Ehud J Schmidt¹

¹Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Eindhoven University of Technology, Eindhoven, Netherlands, ³Siemens Healthcare, Boston, MA, United States

We tested the feasibility of R2*-based temperature mapping using a PETRA UTE sequence to determine the “kill zone” within an ice ball in the kidney during MRI-guided renal cryoablation. R2*-maps were calculated from dual-echo PETRA images acquired during six renal cryoablation cases, and converted to temperature maps using R2*-temperature calibrations performed in swine kidneys. We compared ablation volumes estimated from (a) the -20°C boundary on the temperature maps; (b) the signal void on intra-procedural T2-weighted images; and (c) post-ablation contrast-enhanced MRI as the “gold standard”. Results show that R2*-based temperature maps provided a reliable lower limit of the kill-zone volume.

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