Abstract #0207

Optimal data acquisition for application to the continuous time random walk diffusion model

Thomas Richard Barrick¹, Andrew Mott¹, Diggory North¹, and Franklyn Arron Howe¹

¹Neuroscience Research Centre, St George's, University of London, London, United Kingdom

This study aims to optimise diffusion-weighted MRI (DW-MRI) acquisition for applications involving the continuous time random walk (CTRW) diffusion model. Minimum acquisition time and effects of inversion recovery are considered. Optimisation indicates a 6 minute 4 b-value DW-MRI acquisition is sufficient for diffusion tensor data. Inversion recovery significantly reduces the variability in calculated α, β and ADC due to effects of CSF in grey matter and periventricular white matter. Analysis of water diffusion in brain with the CTRW model may reveal more subtle effects of neuronal damage than conventional DWI.

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