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Abstract #0217

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

Frédéric Grouiller1, Joao Jorge2,3, Francesca Pittau4, Wietske van der Zwaag 5,6, Christoph M Michel7, Serge Vulliémoz 4, Rolf Gruetter2, Maria I Vargas8, and François Lazeyras1

1Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Institute for Systems and Robotics, Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal, 4EEG and Epilepsy Unit, Department of Neurology, Geneva University Hospital, Geneva, Switzerland, 5Biomedical Imaging Research Center (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 7Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland, 8Division of Neuroradiology, Geneva University Hospital, Geneva, Switzerland

The aim of this study was to demonstrate that EEG can be used safely at ultra-high field to locate epileptic focus and functional eloquent cortex in patients. We recorded simultaneous EEG-fMRI at 7T in 9 patients. Despite large artifacts in intra-MRI EEG recordings, it was possible to detect interictal epileptiform discharges and to perform noise-sensitive topography-related analyses. Using an optimized setup and appropriate artifact removal algorithms, localization of epileptic networks and of functional eloquent cortex is possible at ultra-high field. Therefore, the increased fMRI sensitivity offered by this technology may be beneficial to improve presurgical evaluations of patients with epilepsy.

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