Abstract #0217

Presurgical brain mapping in epilepsy using simultaneous EEG and functional MRI at ultra-high field: feasibility and first results

Frédéric Grouiller¹, Joao Jorge^2,3, Francesca Pittau⁴, Wietske van der Zwaag ^5,6, Christoph M Michel⁷, Serge Vulliémoz ⁴, Rolf Gruetter², Maria I Vargas⁸, and François Lazeyras¹

¹Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, ²Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Institute for Systems and Robotics, Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal, ⁴EEG and Epilepsy Unit, Department of Neurology, Geneva University Hospital, Geneva, Switzerland, ⁵Biomedical Imaging Research Center (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁶Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ⁷Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland, ⁸Division of Neuroradiology, Geneva University Hospital, Geneva, Switzerland

The aim of this study was to demonstrate that EEG can be used safely at ultra-high field to locate epileptic focus and functional eloquent cortex in patients. We recorded simultaneous EEG-fMRI at 7T in 9 patients. Despite large artifacts in intra-MRI EEG recordings, it was possible to detect interictal epileptiform discharges and to perform noise-sensitive topography-related analyses. Using an optimized setup and appropriate artifact removal algorithms, localization of epileptic networks and of functional eloquent cortex is possible at ultra-high field. Therefore, the increased fMRI sensitivity offered by this technology may be beneficial to improve presurgical evaluations of patients with epilepsy.

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