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Abstract #0222

Hemodynamic Alterations in Posttraumatic Stress Disorder and Mild Traumatic Brain Injury

Gopikrishna Deshpande1,2,3, D Rangaprakash1, Wenjing Yan1, Jeffrey S Katz1,2,3, Thomas S Denney1,2,3, and Michael N Dretsch4,5

1AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, 2Department of Psychology, Auburn University, Auburn, AL, United States, 3Alabama Advanced Imaging Consortium, Auburn University and University of Alabama Birmingham, Birmingham, AL, United States, 4U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, United States, 5Human Dimension Division, HQ TRADOC, Fort Eustis, VA, United States

Functional MRI is an indirect measure of neural activity, as it is the convolution of the hemodynamic-response function (HRF) and a latent neural response. Recent studies show variance in HRF across brain regions and subjects. This raises the question of reliability of fMRI results if, for example, a canonical HRF is used in analysis. Using whole-brain resting-state fMRI, we employed blind hemodynamic deconvolution to estimate HRF parameters. We uncovered hemodynamic alterations in Soldiers with PTSD and mTBI, and found that certain subcortical and default-mode network regions showed significant alterations in HRF.

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