Abstract #0222

Hemodynamic Alterations in Posttraumatic Stress Disorder and Mild Traumatic Brain Injury

Gopikrishna Deshpande^1,2,3, D Rangaprakash¹, Wenjing Yan¹, Jeffrey S Katz^1,2,3, Thomas S Denney^1,2,3, and Michael N Dretsch^4,5

¹AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States, ²Department of Psychology, Auburn University, Auburn, AL, United States, ³Alabama Advanced Imaging Consortium, Auburn University and University of Alabama Birmingham, Birmingham, AL, United States, ⁴U.S. Army Aeromedical Research Laboratory, Fort Rucker, AL, United States, ⁵Human Dimension Division, HQ TRADOC, Fort Eustis, VA, United States

Functional MRI is an indirect measure of neural activity, as it is the convolution of the hemodynamic-response function (HRF) and a latent neural response. Recent studies show variance in HRF across brain regions and subjects. This raises the question of reliability of fMRI results if, for example, a canonical HRF is used in analysis. Using whole-brain resting-state fMRI, we employed blind hemodynamic deconvolution to estimate HRF parameters. We uncovered hemodynamic alterations in Soldiers with PTSD and mTBI, and found that certain subcortical and default-mode network regions showed significant alterations in HRF.

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