Abstract #0223

Assessment of brain cognitive functions in patients with vitamin B12 deficiency using resting state functional MRI

Lalit Gupta¹, Rakesh K Gupta², Pradeep K Gupta², Hardeep Singh Malhotra³, Indrajit Saha⁴, and Ravindra K Garg³

¹Philips India Ltd., Bangalore, India, ²Department of Radiology, Fortis Memorial Research Institute, Gurgaon, India, ³Department of Neurology, King George Medical University, Lucknow, India, ⁴Philips India Ltd., Gurgaon, India

The alterations in the brain cognitive functions due to vitamin B12 deficiency and reversibility of these alterations following therapy was studied using resting state fMRI. Regional Homogeneity (ReHo) was used to assess functional changes in patients with vitamin B12 deficiency. ReHo was significantly lower in patients than controls in the entire cerebrum and in the brain networks associated with cognition control i.e. default mode, cingulo-opercular and fronto-parietal network. We conclude that the brain networks associated with cognition control, in particular pre-frontal regions, are altered in patients with vitamin B12 deficiency that partially recovered following six weeks of replacement therapy.

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