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Abstract #0224

Longitudinal Changes in Intrinsic Brain Activity in Cirrhotic Patients Before and One Month After Liver Transplantation

yue cheng1, Li-xiang Huang1, Shuang-shuang Xie1, Tian-yi Qian2, and Wen Shen1

1Tianjin First Central Hospital, Tianjin, China, People's Republic of, 2Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of

In this study, we evaluated brain activity changes in cirrhotic patients referred for liver transplantation (LT). Twenty cirrhotic patients and 25 healthy controls were included. Amplitude of low-frequency fluctuation (ALFF) values were compared between cirrhotic patients (pre- and post-LT) and healthy controls as well as patients pre- and post-LT. In cirrhotic patients, decreased ALFF in most brain regions can be reversed one month after LT, and the increased ALFF in temporal and frontal lobe may also return to normal. The reduced ALFF in the right supplementary motor area, inferior parietal lobule and calcarine persisted. One month after LT, the spontaneous brain activity partially renormalized, but complete cognitive function restoration may need a longer time.

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